NASSOUR LAB

ABOUT

Cancers arise through an evolutionary process, as genetic and epigenetic changes accumulate in somatic cells and allow them to escape the proliferative restraints that normally control cell growth. Our lab studies various aspects of telomere biology, with a focus on understanding how dysfunctional telomeres create barriers to cell proliferation and limit cancer development.

Our research integrates expertise in cell biology, molecular biology, biochemistry, and single-cell multiomics to explore the interplay between telomere function, innate immune signaling, and autophagy—and how they impact cancer initiation.

We focus on these aspects of telomere function in aging and cancer:
• Regulation of DNA damage response and repair pathways at telomeres
• Genomic consequences of telomere dysfunction
• Telomeric DNA damage, autophagy, and innate immunity

We strive to create a supportive, diverse, and inclusive lab environment with exceptional training and career development opportunities for fellows and students. We encourage you to explore our website and contact us for discussions, collaborations, or career opportunities.