Telomeres as hotspots for innate immunity and inflammation.

Nassour J, Przetocka S, Karlseder J. DNA Repair 2023. PMID: 37951043.

Flow Cytometry-based Method for Efficient Sorting of Senescent Cells.

Goy E, Martin N, Drullion C, Saas L, Molendi-Coste O, Pineau L, Dombrowicz D, Deruy E, Bauderlique-Le-Roy H, Samyn O, Nassour J, De Launoit Y, Abbadie C. Bio Protoc 2023. PMID: 37056241.

TZAP overexpression induces telomere dysfunction and ALT-like activity in ATRX/DAXX-deficient cells.

Moreno S, Miralles Fuste J, Kaiser M, Su Zhou Li J, Nassour J, Haggblom C, Lazzerini Denchi E, and Karlseder J. iScience 2023.

Telomere-to-mitochondria signalling by ZBP1 mediates replicative crisis.

Nassour J, Aguiar LG, Correia A, Schmidt TT, Mainz L, Przetocka S, Haggblom C, Tadepalle N, Williams A, Shokhirev MN, Akincilar SC, Tergaonkar V, Shadel GS, Karlseder J. Nature 2023. PMID: 36755096.


Selective pericentromeric heterochromatin dismantling caused by TP53 activation during senescence.

Mendez-Bermudez A, Lototska L, Pousse M, Tessier F, Croce O, Latrick CM, Cherdyntseva V, Nassour J, Xiaohua J, Lu Y, Abbadie C, Gagos S, Ye J, Gilson E. Nucleic Acids Res. 2022. PMID: 35819196.

The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion.

Goy E, Tomezak M, Facchin C, Martin N, Bouchaert E, Benoit J, de Schutter C, Nassour J, Saas L, Drullion C, Brodin PM, Vandeputte A, Molendi-Coste O, Pineau L, Goormachtigh G, Pluquet O, Pourtier A, Cleri F, Lartigau E, Penel N, Abbadie C. Elife 2022. PMID: 35302491.


Telomeres and Cancer: Resolving the Paradox.

Nassour J, Schmidt TT, Karlseder J. Annu Rev Cancer Biol. 2021. PMID: 34532611.


Autophagic cell death restricts chromosomal instability during replicative crisis.

Nassour J, Radford R, Correia A, Fusté JM, Schoell B, Jauch A, Shaw RJ, Karlseder J. Nature 2019. PMID: 30675059.

2013 - 2018

HIC1 (hypermethylated in cancer 1) SUMOylation is dispensable for DNA repair but is essential for the apoptotic DNA damage response (DDR) to irreparable DNA double-strand breaks (DSBs).

Paget S, Dubuissez M, Dehennaut V, Nassour J, Harmon BT, Spruyt N, Loison I, Abbadie C, Rood BR, Leprince D. Oncotarget 2017. PMID: 27935866.

A novel role for DNA single-strand breaks in senescence and neoplastic escape of epithelial cells.

Nassour J, Abbadie C. Mol Cell Oncol. 2016. PMID: 27857969.

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells.

Nassour J, Martien S, Martin N, Deruy E, Tomellini E, Malaquin N, Bouali F, Sabatier L, Wernert N, Pinte S, Gilson E, Pourtier A, Pluquet O, Abbadie C. Nat Commun. 2016. PMID: 26822533.

Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion.

Deruy E*, Nassour J*, Martin N, Vercamer C, Malaquin N, Bertout J, Chelli F, Pourtier A, Pluquet O, Abbadie C. Cell Death Dis. 2014. PMID: 25522271.
*Equal Contribution

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.

Dehennaut V, Loison I, Dubuissez M, Nassour J, Abbadie C, Leprince D. J Biol Chem. 2013. PMID: 23417673.